The consequence revealed that the high- and low- METAscore groups exhibited distinct mutation characteristics and the genes with a high mutation frequency in TTN, MUC4, PIK3CA, and MUC16 which all correlated with EMT (Chen et al., 2018) and critical cancer pathways including PI3K/AKT (Razia et al., 2019) and JAK2/STAT3 (Shen et al., 2020) (Figures 7A,B) in CESC. This evidence concerns the gene STAT3 and cancer.