GPT and diabetes mellitus: As evidence for the role of AGEs in DM-CMP pathogenesis, the cleavage of preformed AGE crosslinks with ALT-711 attenuates the diabetes-associated cardiac abnormalities in rats (103), and the administration of a RAGE antagonist in a rat model of T1DM prevents AGEs/RAGE signaling-mediated increases in myocardial collagen, fibrosis, stiffness and diastolic dysfunction (104).