PKCβ2 isoform is over-expressed in the myocardium of diabetic animal models and patients with HF (109, 110), and the activation of the PKC/DAG signaling pathway is associated with biochemical and structural changes typical of DM-CMP (e.g., reduced blood flow, increased vascular permeability, basal membrane thickening, ECM deposition, and cardiac hypertrophy) (111–113). This evidence concerns the gene PRRT2 and diabetes mellitus.