More recently, it has been observed a bidirectional crosstalk among leukemic and stromal cells upon L-asparaginase administration, with ALL blasts increasing Glutamine Synthetase (GS) expression and releasing glutamine, utilized by MSCs for the synthesis of Asn, which is then secreted to sustain ALL cell viability (Chiu et al., 2017). The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.