MYC and Burkitt lymphoma: Interestingly, a positive feedback loop between c-MYC and AP-1 factors has been proposed in BL, with increased c-MYC levels leading to increased AP-1 phosphorylation and binding to the Igκ Ei and E3′ enhancers, potentially increasing expression of translocated c-MYC in Igκ/c-MYC-BL and possibly that of the unaffected allele on chromosome 8 (Ding et al., 2020).