In AKI animal models, accumulated kidney lipids went with downregulated FAO-related factors, while activation of PPARα (Li et al., 2005, 2009; Nagothu et al., 2005), PGC1α (Tran et al., 2011, 2016), and CPT1 (Idrovo et al., 2012) provided renal protective effects. This evidence concerns the gene PPARA and acute kidney injury.