YTHDF1 and neoplasm: Wang et al. (2019) revealed that upregulated METTL3 promoted dendritic cell (DC) activation and maturation, and that METTL3 downregulation inhibited T cell activation and aggregation. Han et al. (2019) demonstrated that inhibiting YTHDF1 enhanced CD8+ T cell tumor infiltration and immunotherapy efficacy in a murine tumor model.