Both the mRNA and protein expression levels of WTAP, KIAA1429, RBM15, RBM15B, METTL3, HNRNPs, YTHDF1, YTHDF2, YTHDF3, IGF2BPs, and FTO were markedly higher in HCC tissues (Figure 1A). Here, METTL3 is linked to hepatocellular carcinoma.