Although NFs+IL-8 induced the tumor growth of HEY-A8 cells faster than did HEY-A8 cells alone, cancer cells pretreated with CAF CM+IL-8 antibody to neutralize the function of IL-8, generated the similar tumor growth to that induced by HEY-A8 cells alone (Figures 3C,D). This evidence concerns the gene CXCL8 and cancer.