We then investigated the relationship between Notch3 and IL-8 levels in patients diagnosed with ovarian cancer by examining the level of IL-8 in the ascites by ELISA and the expression of Nocth3 in tumor tissue samples from 12 ovarian cancer patients by immunohistochemical staining (Figures 6B,C). The gene discussed is CXCL8; the disease is ovarian carcinoma.