Though MMPs are not typically viewed as important metabolic modulators, there is emerging evidence that MMP-2, MMP-9, and MMP-14 are potent modulators of cholesterol metabolism, a crucial pathway in glioblastoma growth and invasion (Ulasov et al., 2014; Hernandez-Anzaldo et al., 2016). This evidence concerns the gene MMP9 and glioblastoma.