Regarding the five m6A regulator-based risk signatures, four of five m6A regulators, including YTHDF1, YTHDF2, WTAP, and METTL3, could facilitate the progression of HCC, and the results were confirmed by previous reports (Chen et al., 2018, 2019; Liu et al., 2020; Zhang C. et al., 2020). The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.