Tang et al. (2020) reported that m6A demethylase inhibits tumor by mediating Wnt signaling. Zhao et al. (2020) reported that m6A RNA modification regulates mTOR signal pathway in gastrointestinal cancer. Also, Zhang H. et al. (2020) found that the m6A regulator METTL3 promotes the progression of retinoblastoma through mTOR signal pathway. The findings revealed that m6A regulators could affect the progression of HCC by targeting Wnt and mTOR pathways, which could provide a new therapeutic strategy for the treatment of HCC. The gene discussed is METTL3; the disease is hepatocellular carcinoma.