SERPINE1 and chronic kidney disease: There is, in fact, considerable overlap among the SASP, the chronic kidney disease-associated secretory phenotype (CASP) and the SASP aging and disease biomarker gene sets that includes increases in the scar-promoting proteins TGF-β1, PAI-1 (SERPINE1) and CNN2 (Wang et al., 2017; Basisty et al., 2020).