The prolonged G1 and G2/M arrest in severe AKI, although necessary to insure DNA fidelity and maintain genome integrity, may adversely impact regenerative growth if cell cycle re-entry is excessively delayed while promoting maladaptive fibrotic repair in a TGF-β1-rich environment (Yang et al., 2010; Moonen et al., 2018). The gene discussed is TGFB1; the disease is acute kidney injury.