In this study, MDA-MB-231 BC MCS cells grown under conditions of s-μg exhibited a differential regulation of the expression of ECM, and FA genes, such as ITGB1, VCL and TLN1. RPM exposure of MCF-7 BC MCS cells resulted in significant changes in the gene expression of PXN, TLN1, and CDH1, and the WNT-β-catenin target genes BCL9, JUN and MYC. The focal adhesion complex as well as cell adhesion molecules and the cytoskeleton are important gravisensors in μg. Here, VCL is linked to breast cancer.