In this study, MDA-MB-231 BC MCS cells grown under conditions of s-μg exhibited a differential regulation of the expression of ECM, and FA genes, such as ITGB1, VCL and TLN1. RPM exposure of MCF-7 BC MCS cells resulted in significant changes in the gene expression of PXN, TLN1, and CDH1, and the WNT-β-catenin target genes BCL9, JUN and MYC. The focal adhesion complex as well as cell adhesion molecules and the cytoskeleton are important gravisensors in μg. The gene discussed is PXN; the disease is breast cancer.