In the event of chronic liver injury, capillarized LSECs play pivotal roles in initiating and aggravating liver fibrosis by multiple mechanisms, including impaired sinusoidal microcirculation, hepatocyte metabolism (Hammoutene and Rautou, 2019), HSC activation (Deleve et al., 2008; Xie et al., 2012), and abnormal angiocrine with reduced expression of hepatocyte mitogens, such as HGF and Wnt2a (Rafii et al., 2016; Duan et al., 2018). The gene discussed is HGF; the disease is Hepatic fibrosis.