RPTOR and obesity due to melanocortin 4 receptor deficiency: While deletion of Raptor in WAT also results in defective WAT expansion, lipodystrophy, and resistance to diet-induced obesity (Lee et al., 2016), the overexpression of Deptor, a negative regulator of mTOR, promotes adipogenesis and mice gain more weight upon high-fat feeding (Laplante et al., 2012).