They were selected because BACE1 is the first enzyme involved in APP splicing (Bettens et al., 2009; Ridler, 2018), and APOE is a well-known genetic risk factor for late-onset AD (LOAD) (Schreiber et al., 2017; Prendecki et al., 2019; Weintraub et al., 2019). Here, APP is linked to Alzheimer disease.