APP and Alzheimer disease: Here, we found a significant decrease of SV2A expression at the mRNA level in the hippocampus of AD patients compared with non-AD subjects as per the Allen Brain database analysis (Figure 1), indicating that changes in SV2A expression influence synaptic function in AD and suggesting that SV2A may serve as a key regulator to AD-related proteins, such as Aβ and APP, two hallmarks of AD (Muller et al., 2017).