IL10 and tick-borne encephalitis: The efficacy of immune response against TBEV infection is also influenced by host genetic factors as severe manifestation of TBE were associated with polymorphisms in TLR3 (Kindberg et al., 2011; Barkhash et al., 2013; Mickiene et al., 2014), CCR5 (Mickiene et al., 2014),CD209 (Barkhash et al., 2012), and IL10 genes (Barkhash et al., 2016).