On the other hand, D-4F was reported to inhibit the proliferation of ovarian tumor cell line ID8 cell and ovarian tumor development by inducing the expression and activity of mitochondrial manganese (MnSOD), which is the primary antioxidant enzyme that protects cells from reactive oxygen species (ROS) inducing damage to mitochondrial element injury (35, 61). The gene discussed is SOD2; the disease is ovarian neoplasm.