For example, A differential expression of the circulating miRNAs from 50 patients diagnosed with chronic HBV infection and hepatic fibrosis based on Scheuer’s staging criteria found the majority of the target genes of the identified miRNAs affected hepatic fibrosis via the TGF−/Smad, Wnt, MAPK, Jak/STAT and VEGF pathways (160). The gene discussed is SOAT1; the disease is Hepatic fibrosis.