(16) found that knockdown of circ-ARL3 suppressed HBV-positive cell proliferation and invasion, whereas these effects were inhibited by silencing of miR-1305, suggesting that the circ-ARL3/miR-1305 regulatory axis exists in HCC cells and may be a promising treatment target for patients with HBV-HCC. This evidence concerns the gene ARL3 and hepatocellular carcinoma.