Importantly, circ-ARL3 serves as a molecular sponge of miR-1305, antagonizing the inhibitory effects of miR-1305 in a cohort of target oncogenes (16), including WNT2 (29), ubiquitin-conjugating enzyme E2 T (UBE2T) (30), double minute 2 homolog (MDM2) (31), transforming growth factor-beta2 (TGF-β2) (32), and RNA Polymerase III Subunit G (POLR3G) (33), thereby facilitating HBV-HCC progression. The gene discussed is ARL3; the disease is hepatocellular carcinoma.