In the case-control comparison, we found hyper-methylation of genes belonging to the Wnt signaling pathway (SFRP1, SFRP2, DKK1, DKK2, and WIF1), the TGF-Beta;/SMAD pathway (RUNX3), two tumor suppressor genes (PCDH10 and OPCML), and a gene that acts both as an oncogene and a tumor suppressor, depending on the cellular context (TMEFF2). The gene discussed is DKK1; the disease is neoplasm.