While no consistent similarities between AML and CML were identified, dysregulation of genes involved in sustaining glutamate (i.e., PRODH), aspartate (i.e., AST1), alanine (i.e., GPT), asparagine (i.e., ASNS), and cysteine (i.e., CTH) levels suggest potential vulnerabilities involving these amino acids. This evidence concerns the gene ASNS and acute myeloid leukemia.