In this study, we revealed that the combined expression level of 12 TFs (XRCC5, NFYC, HOXA1, DLX5, RREB1, PIAS4, MAFB, NR5A2, LMO4, CRTC1, SRF and CNOT8) predicted RFS in HNSCC patients. Here, NR5A2 is linked to head and neck squamous cell carcinoma.