In this study, we revealed that the combined expression level of 12 TFs (XRCC5, NFYC, HOXA1, DLX5, RREB1, PIAS4, MAFB, NR5A2, LMO4, CRTC1, SRF and CNOT8) predicted RFS in HNSCC patients. The gene discussed is RREB1; the disease is head and neck squamous cell carcinoma.