In addition, a significant correlation was observed between PGK1 mRNA upregulation and poor PFS and PPS in patients with TP53 mutations compared with patients with wild-type TP53. Therefore, PGK1 may play a key role in glycolysis of ovarian cancer and be used as a biomarker for evaluating poor prognosis in patients with ovarian cancer. Here, TP53 is linked to ovarian cancer.