The results of multivariate Cox regression analysis showed that the high expression of FTO (HR=1.82, P=0.010, 95% CI: 1.15-2.87), lymph node metastasis (HR=1.32, P<0.001, 95% CI: 1.12-1.56), distant metastasis (HR=2.05, P=0.022, 95% CI: 1.11-3.79) as well as older age (HR=1.92, P=0.001, 95% CI:1.28-2.87) were independent predictors (Figures 1A, B). This evidence concerns the gene FTO and metastatic malignant neoplasm in the lymph nodes.