In this study, we found that FTO-KD effectively suppressed the migration and invasion abilities of GC cells, but could not affect the proliferation of both BGC823 and MGC803 cells, and FTO-OE enhanced the cell migration and invasion ability in MKN7 cells, which were partially consistent with some previous researches (25, 41, 42), suggesting that FTO might lead to poor prognosis by promoting metastasis in GC. The gene discussed is FTO; the disease is gastric cancer.