BRAF and melanoma: Figure 6 illustrates the clinicopathological features of an ulcerated melanocytic malignancy histopathologically composed of large epithelioid cells with Spitz-like features, but immunohstichemically typified as a “classical” melanoma because of its immunohistochemical positivity to the anti-BRAF mutated protein VE1 antibody. Parenthetically, PEM-like (75, 76) and DPN-like melanomas (77, 78) might be differentiated from their “melanocytoma counterpart” based on immunohistochemical and/or genetic findings akin to “classical” melanoma.