BRAF and melanoma: Based on the presence of specific driver mutations, The Cancer Genome Atlas (TCGA) classified melanomas into four molecular subtypes: BRAF-mutated, RAS-mutated, NF1-mutated, and triple wild-type (lack of mutations in all three genes); among the latter were cases characterized by KIT mutations and by early onset of somatic copy number variations in terms of both gene amplifications in KIT, CCND1, CDK4, MITF, and TERT and gene deletion/loss-of-function of TP53 and CDKN2A (9).