NRAS and melanoma: TCGA molecular subtypes correspond to most cases of the classical (Clark’s and McGovern’s) (25, 26) types of melanoma and roughly identify melanoma pathways 1–3 of the WHO 2018 classification; melanoma arising in congenital nevus may be also genetically related to classical melanoma because they harbor multiple DNA copy number changes (17) superimposed to NRAS mutation.