NRAS and melanoma: Since the initiating genetic change of such neoplasms is often an activating mutation of BRAF or NRAS, the three above-mentioned types of melanocytomas are placed within Pathway 1 of melanomagenesis, whose endpoint is superficial spreading melanoma; however, cases of superficial spreading melanoma dysplaying the genetic signature of the above-listed melanocytomas are exceedingly rare.