Like Pathway 1 to melanoma, dysplastic nevi are associated with activating mutations of BRAF or NRAS (18, 29); additional mutation of the TERT promoter and, sometimes, hemizygous loss of CDKN2A are involved in the morphological progression to a “classical” (superficial spreading) melanoma in situ (32). The gene discussed is TERT; the disease is melanoma.