IGF1 and breast carcinoma: Similar to our previous observation in NB cells (10), overexpression of NLRR1 increased the cell growth in NLRR1-low-expressing MCF7 breast cancer cells (Figure 1C) and the activation of ERK in the cells was enhanced when treated with EGF and IGF in dose-dependent manner (Figures 1D, E) and time-dependent manner (Figure S2).