In the training cohort, the univariate analysis suggested that gender (P=0.023), cirrhosis (P<0.001), lymphocyte (P<0.001), platelet (P<0.001), TBil (P<0.001), DBil (P<0.001), Alb (P<0.001), ALT (P<0.001), AST (P<0.001), PT (P<0.001), INR (P<0.001), tumor size (P=0.002), ICG-15R% (P<0.001), blood loss (P<0.001), operation time (P=0.006), NLR (P=0.025), LMR (P<0.001), ANRI (P<0.001) and APRI (P<0.001) were potential risk factors of PHLF. The gene discussed is GPT; the disease is neoplasm.