investigated multiple sclerosis with an autoimmune encephalomyelitis (EAE) model of mice deficient in NRP1 on their T CD4+ lymphocytes (LT CD4+) and showed that mice presented aggravated EAE in contrast to mice over-expressing NRP1 on their LT CD4+, which did not develop EAE (133). Here, NRP1 is linked to multiple sclerosis.