IFNG and neoplasm: In a second step, NRP1 maintains the stability and intratumoral function of LTreg cells via the SEMA-4A signaling pathway (136), and the inhibition of NRP1 in intratumoral LTregs promotes the production of interferon-γ (IFNγ), which leads to the fragility of surrounding LTregs, thereby enhancing anti-tumor immunity and facilitating tumor clearance (139).