In this study we demonstrate that (i) PCAT6 level is increased in NEPC cells and tissues, (ii) Upregulated PCAT6 facilitates NED, proliferation, invasion of PCa cells in vitro and in vivo, (iii) PCAT6 acts as a ceRNA and sponges miR-326 to de-repress Hnrnpa2b1 expression, (iv) PCAT6 promotes PCa cells proliferation, invasion, and NED by regulating miR-326/Hnrnpa2b1 axis. This evidence concerns the gene PCAT6 and posterior cortical atrophy.