ERBB2 and breast neoplasm: In accordance with our previous work (5, 7), the present retrospective analysis of the cohort composed of 107 human primary breast tumor samples confirmed that high ZNF217-E3 mRNA levels: (i) were significantly associated with shorter relapse free survival (RFS) in the whole cohort (p = 0.031 Table 1) and in the Luminal subclass (p = 0.030, Table 1 and Supplementary Figure 2A); (ii) were not informative in the HER2-enriched, or Triple negative subclasses (Table 1).