CD4 and neoplasm: When radiation is combined with CTL therapy, tumor growth inhibition was increasedTumor infiltrating lymphocytes and tumor cell interaction was increased after treatment with radiation therapy and a CTLA-4 blocking antibodyCTLA-4 blockade plus radiation therapy in mice lead to a higher density of CD8+ and CD4+ cells. When CD4+ T cells are depleted, the antitumor activity decreasedWhen PD-1 antibody was combined with radiation, mice with triple negative breast cancer were curedRadiation plus a PD-L1 blockade causes an increased activation of cytotoxic T cells