Previous meta-analysis on non-BFRE (i.e., traditional exercise training) identified higher exercise volumes, compared to lower exercise volumes, resulted in greater improvements in skeletal muscle hypertrophy (Schoenfeld, Ogborn & Krieger, 2017), potentially caused by an increased release of neurohumoral factors (i.e., GH, nitric oxide, vascular endothelial growth factor). This evidence concerns the gene VEGFA and Skeletal muscle hypertrophy.