In addition, a role for EVs released by glial cells, especially microglia, upon ATP activation is emerging in brain diseases (Lombardi et al., 2021), such as traumatic brain injury (Liu et al., 2017) and tauopathy, where ATP‐induced EVs have been implicated in the spreading of tau protein (Ruan et al., 2020). This evidence concerns the gene MAPT and tauopathy.