Following the same steps mentioned previously (the edge file “Yellowbrowmagenta.edges” seen in Supplementary File 4), we just obtained eight core genes and eventually get one AF-associated gene LOXL1 (adj pdis = 0.047, adj ptest = 0.07, GS = 3.0) in RAA (Figure 7B). This evidence concerns the gene LOXL1 and atrial fibrillation.