By the GWAS test set, the AF-associated gene MYH7 (adj pdis = 7.6E–6, adj ptest = 0.014, GS = 3.95) confirmed in previous studies was identified, while four novel biomarkers associated with AF were determined, including ERBB2 (adj pdis = 5.1E–7, adj ptest = 0.013, GS = 3.34), HERC4 (adj pdis = 6E–6, adj ptest = 0.0042, GS = 3.0), MYPN (adj pdis = 0.0004, adj ptest = 0.02, GS = 2.07), and PBXIP1 (adj pdis = 0.00036, adj ptest = 0.0002, GS = 3.3). The gene discussed is MYPN; the disease is atrial fibrillation.