HERC4 and atrial fibrillation: Subsequently, the six AF-associated loci were verified from the LAA of 30 clinical patients by RT-qPCR, and the data showed that the expression of ERBB2, MYH7, and MYPN in AF group had significant change compared with that in SR group, while that of HERC4, LOXL1, and PBXIP1 had no change (Figure 8).