Similarly, in bladder tumors, the effect of NF-kappa B activation on tumorigenesis has also been reported (Levidou et al., 2008) and in our study, both up-regulated genes in the U11 overexpression group and down-regulated genes in the U11 knockout group were mainly enriched in the NF-kappa B signaling pathway. The gene discussed is RNU11; the disease is urinary bladder neoplasm.