STAT3 and cancer: Comparatively, the low-risk group was significantly associated with multiple cancer-related processes, such as angiogenesis, apoptosis, epithelial-mesenchymal transition, hypoxia, IL6_JAK_STAT3 signaling, inflammatory response, interferon γ response, KRAS signaling, TNFa signaling via NF-κB, and P53 pathway (Figure 6D).