Recent discoveries have shown that CD8+ T cells can promote tumor ferroptosis during immune checkpoint therapy with PD-L1 blockade, and suppression of ferroptosis inhibited the anti-tumor effect of PD-L1 blockade, revealing that T cell-induced tumor ferroptosis is an anti-tumor immunological mechanism (Stockwell and Jiang, 2019; Wang et al., 2019). This evidence concerns the gene CD8A and neoplasm.