The association between ADAMTS13 activity and AF (b = 0.00006, se < 0.001, p = 0.0986) could not be demonstrated by the standard IVW or by HF (b = −0.00004, se < 0.001, p = 0.0544), ischemic stroke (b = −0.00005, se < 0.001, p = 0.1893), and VTE (b = −0.00005, se < 0.001, p = 0.1546) based on UK Biobank. Here, ADAMTS13 is linked to atrial fibrillation.