Second top signal in IROD2 group of long-term diabetes suggested reduced frequency of the risk allele in the imprinting gene KCNQ1 (rs 163,184) that has also been shown to be expressed in the pancreatic β-cells and to act through impaired islet function on the risk of future T2D (Jonsson et al., 2009). The gene discussed is KCNQ1; the disease is type 2 diabetes mellitus.