For GJB2 gene: 271 heterozygotes (5.29%) and 7 homozygotes, among which nine cases (3.24%, 9/278) carried pathogenic deafness-associated variants, including seven homozygotes and another two cases with two variants identified (phase unknown) (c.[109G > A] + [299_300delAT] and c.[235delC] + [257C > G]) (Table 3). Here, GJB2 is linked to deafness.