Lastly, heterozygous deficiency of IL-1R antagonist, overexpressed in mice carrying the Sst1 (super susceptibility to tuberculosis 1) locus, almost completely rescued these mice from their type-I IFN driven early mortality and excessive pulmonary CFU burden during Mtb Erdman strain infection, again highlighting the protective effect of IL-1R signalling (198). This evidence concerns the gene IL1R1 and tuberculosis.