From this perspective, recent approaches are being evaluated: epigenetic reprogramming of M2-like TAMs into M1-like TAMs (144); increasing phagocytic activity by CD47/SIRPα blockade (145, 146); engineering Chimeric Antigen Receptors for Phagocytosis (CAR-P) to increase tumor cell killing (147, 148). This evidence concerns the gene SIRPA and neoplasm.