In addition, the percentages of IL-12+ and TNF-α+ cDCs were found to be significantly lower in scrub typhus patients compared to HCs (for IL-12+ cells, median 9.3% versus 28.8%, P = 0.003; for TNF-α+ cells, median 24.7% versus 49.0%, P = 0.019; Figure 3D). The gene discussed is TNF; the disease is scrub typhus.