Immune suppression induced by the HLA-G/ILTs signaling pathway includes inhibition of cytotoxicity (64), inflammatory cytokine production (65), chemotaxis and proliferation of T cells and NK cells (66, 67), inhibition antibody production of B cells and maturation of antigen presenting cells (68, 69), and dampen the anti-tumor functions of invariant natural killer T (iNKT) cells and tumor-infiltrating CD8+PD-1−ILT-2+ T cells (70, 71). Here, CD8A is linked to neoplasm.