In addition to immune suppressive functions, HLA-G/ILTs can promote intratumor vascular remodeling by enhancing vascular endothelial growth factor-C (VEGF-C) expression, and increase tumor metastasis by inducing cancer promoting factor matrix metalloproteinases (MMPs) expression (74, 75) (Figure 1). The gene discussed is HLA-G; the disease is neoplasm.