IL21 and Tumor Lysis Syndrome: Interestingly, an increase of IL-21 and IL21R transcripts and of IL-21 secretion is associated with the presence of TLS in Nasal Inverted Papilloma, a benign tumor, strengthening the idea that IL-21/IL21R axis plays a critical role in the response to anti-ICP therapy, possibly through the formation of TLS (67).