It was shown that the expression of EPOR/βcR was greatly triggered by IR injury in kidneys, and in particular located in tubular epithelial cells (TECs) (11), while its ligand HBSP or CHBP protected the kidney against IR-induced AKI, as well as cyclosporine A-induced fibrotic damage in kidneys (12). The gene discussed is EPOR; the disease is acute kidney injury.