In IL-13–overexpressing transgenic mouse AD model, HC030031 administration markedly decreased IL-13–induced AD itch, and reduced TRPA1 expression in skin, but did not completely abrogate IL-13–induced itch responses, suggesting that TRPA1-independent mechanisms regulate the pathogenesis of IL-13–induced itch (44). This evidence concerns the gene TRPA1 and Alzheimer disease.