TRPV1 antagonist AMG517 aggravated the squaric acid dibutylester (SADBE)-induced skin inflammation, whereas it was not affected by administration of a selective TRPA1 channel blocker A967079, suggesting that TRPV1, but not TRPA1, plays a critical role in modulating ear edema in the SADBE-induced allergic contact dermatitis model (34). Here, TRPV1 is linked to allergic contact dermatitis.