Evidences reinforcing the information of Th2-driven modulation of TRP channels in progression of AD include IL-13–enhancing TRPV1 (79) and TRPA1 transcription (44), IL-31 transcriptionally regulating TRPV1 (80), and rapidly sensitizing TRPV1 channel activity (see below), and Pro-Th2 cytokine TSLP upregulating TRPA1 synthesis in sensory neurons (10). Here, IL31 is linked to Alzheimer disease.