The blockade of activation of TRPV1 by PAC-14028 is confirmed in murine AD models induced by Dermatophagoides farina (Df)- and oxazolone (OXZ), whose AD-like symptoms have been improved, including serum IgE increase, mast cell degranulation, scratching behavior, and clinical severity of dermatitis (136). The gene discussed is IGHE; the disease is Alzheimer disease.