AD-like phenotypes were found to be attenuated by HC030031 in this model, but not by TRPV1 inhibitor, approving that TRPA1, but not TRPV1, is related closely to skin edema, keratinocyte hyperplasia, nerve growth, leukocyte infiltration, and histamine-independent scratching behavior in these mice (38). The gene discussed is TRPV1; the disease is Alzheimer disease.