CD8A and neoplasm: Surprisingly, in 80% of the mice the HPV-16 E7 transcript contained a single amino-acid mutation in the CD8 epitope region (RAHYNIVTF) (Figure 6D), which allowing tumor to escape recognition by Z13Mad25Anaxa elicited HPV-E7 specific CD8 T cells, and proliferate despite the presence of functional CD8 T cells.