Recently, it has been reported that increased levels of IL-6 enhance the inflammatory process and contribute to cytokine storm thereby worsening prognosis (72); however, targeting IL-6 receptors (IL-6r) with a specific monoclonal antibody (tocilizumab) has been shown to mediate an effective therapeutic option in COVID-19 patients who are at risk of developing cytokine storms (69). This evidence concerns the gene IL6 and COVID-19.