And most of them reported that the mRNA expression of IQGAP2 was negatively associated with a variety of cancers, including hepatocellular carcinoma, gastric cancer, bladder cancer, breast cancer, kidney cancer, lung cancer, and so on, indicating the potential of IQGAP2 being a tumor suppressor (30–33). The gene discussed is IQGAP2; the disease is hepatocellular carcinoma.