Some DEGs including SERPINA3, SLPI, CBF, FTCD, TASPN7, VCAN, TIMP1 and FOS might be novel biomarkers to facilitate timely diagnosis and early therapeutic intervention in donor kidney preservation, implantation or post-transplantation, in particular, effectively improve the donor quality and allograft survival of DD. The gene discussed is TIMP1; the disease is dentin dysplasia.