We observed that the SLEDAI score in the SLE group was negatively correlated to the abundance of Acholeplasma, Capnocytophaga and Leptotrichia, etc., and the serum levels of C3 in patients were negatively correlated with the abundance of Akkermansia, Bacteroides, and Ruminococcus in fecal samples (Figure 3A). The gene discussed is C3; the disease is systemic lupus erythematosus.