After STZ administration, the body weight and insulin levels of the diabetic rats were significantly decreased compared to those of other groups [BW-4w: F (10, 110) = 10.14, P < 0.0001; BW-8w: F (14, 150) = 31.99, P < 0.0001; Insulin: T2DM-4w vs NC-4w, P < 0.01; T2DM-4w vs HFD-4w, P < 0.001; T2DM-8w vs NC-8w, P < 0.001; T2DM-8w vs HFD-8w, P < 0.0001]. The gene discussed is INS; the disease is type 2 diabetes mellitus.